TLN1-NGFR Interaction Data for Castration-Resistant Prostate Cancer Research

Mass spectrometry and transcriptome sequencing data underpin a study on the role of Talin-1 in castration-resistant prostate cancer. The dataset, shared by Sixin Li under a CC-BY-4.0 license, includes results from clinical samples and in vitro assays. It was last updated on 2026-04-23.

Use Cases

• Analyze differential protein expression between hormone-sensitive and castration-resistant prostate cancer based on mass spectrometry data.
• Investigate gene expression changes following TLN1 knockdown based on transcriptome sequencing results.
• Study protein-protein interaction networks based on the confirmed TLN1-NGFR binding.
• Model the impact of TLN1 on signaling pathways like PI3K-AKT and MAPK based on Western blot analysis data.

Strengths

• Includes data from 59 prostate cancer and 17 benign prostatic hyperplasia clinical tissue samples.
• Functional validation from multiple assays (CCK-8, colony formation, Transwell) and a nude mouse xenograft model.
• Mechanistic insights are supported by co-immunoprecipitation and molecular docking experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 65.3 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data generated via mass spectrometry, immunohistochemistry, qPCR, Western blot, functional assays, and transcriptome sequencing of clinical and cell line samples.

Freshness

Last updated 2026-04-23 05:35:43; freshness should be verified.