Schistosoma mansoni Egg Proteome from Infected Mouse Liver and Intestine

Lucie Jedličková published a dataset on 2026-05-15 containing the in situ proteomic profile of Schistosoma mansoni eggs within host tissues. The data was generated using laser microdissection of periovular granulomas from infected mouse livers and small intestines during acute and chronic infection phases, followed by high-resolution mass spectrometry. It identifies a core set of 149 parasite proteins and reveals organ- and phase-specific protein expression patterns.

Use Cases

• Identify potential vaccine or drug targets based on the conserved core set of 149 parasite proteins.
• Study tissue-specific immune modulation based on organ-dependent protein profiles.
• Analyze temporal changes in parasite protein expression based on acute versus chronic infection phases.
• Investigate differences in egg fate and host response based on protein profiles from trapped hepatic eggs versus transiting intestinal eggs.

Strengths

• Provides the first in situ characterization of egg-derived proteins in host tissues.
• Identifies a specific core set of 149 parasite proteins.
• Compares protein profiles across two organs (liver, intestine) and two infection phases (acute, chronic).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived exclusively from a mouse model; direct applicability to human infection may be limited.

Provenance

Source

figshare

Collection Method

Laser microdissection of periovular granulomas followed by high-resolution mass spectrometry.

Time Range

Covers acute and chronic phases of infection.

Freshness

Last updated 2026-05-15 05:47:23; freshness should be verified.

Geography

Laboratory study using infected mice; geographic origin of samples is unspecified.