Human Interventions That Decrease Next-Generation Epigenetic Aging Clocks

A systematic review of 41 human studies identified interventions affecting next-generation epigenetic aging clocks. The dataset, compiled by Adiv A. Johnson and last updated in May 2026, lists pharmaceutical, lifestyle, and clinical interventions that were found to decrease, have no effect on, or accelerate epigenetic age. It includes reported effect sizes and compares the responsiveness of different clock models.

Use Cases

• Identify promising longevity interventions based on reported decreases in epigenetic age.
• Compare the responsiveness of different next-generation epigenetic clocks to interventions.
• Analyze the range of effect sizes reported for interventions like exercise, diet, and pharmaceuticals.
• Investigate interventions that showed no detectable effect or accelerated epigenetic aging.

Strengths

• Based on a systematic search of 41 identified human studies.
• Compares multiple next-generation epigenetic clocks and their frequency of use.
• Explicitly lists interventions with positive, null, and negative effects on epigenetic age.

Limitations

• Row count and specific column-level documentation are unknown.
• The 17.5 KB file size suggests a limited scope, likely a summary table rather than raw study data.
• Freshness should be verified as the last update was 2026-05-28.

Provenance

Source

figshare, authored by Adiv A. Johnson.

Collection Method

Systematic searches of the literature to identify relevant human studies.

Freshness

Last updated 2026-05-28 22:03:24.