PANDAS: Autoantibody Screening Results from Nucleic Acid Protein Programmable Array

Jelena Eremija published autoantibody screening data for Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) on figshare in April 2026. The dataset contains results from unbiased screening using a Nucleic Acid Protein Programmable Array (NAPPA), comparing children with PANDAS to those with autism spectrum disorder and healthy controls. It includes 1,235 initial non-overlapping protein targets and 117 autoantibody targets identified exclusively in the PANDAS group.

Use Cases

• Identify potential autoimmune targets in PANDAS based on the 1,235 non-overlapping protein targets.
• Analyze the heterogeneity of autoantibody profiles based on the finding that 67.5% of PANDAS-positive targets were reactive in only a single patient.
• Perform functional enrichment analysis on PANDAS-specific targets, focusing on transcription factors, apoptosis regulators, and neural development proteins.
• Evaluate the diagnostic performance of autoantibody-based classifiers for distinguishing PANDAS from ASD and healthy controls.
• Investigate shared autoantibody reactivity across neuropsychiatric conditions as described in the results.

Strengths

• Dataset includes results from a secondary screen identifying 117 autoantibody targets exclusive to the PANDAS group.
• Functional enrichment analysis revealed specific biological categories for PANDAS-specific targets, such as transcription factors and chromatin modifiers.
• The dataset is openly licensed under CC-BY-4.0, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description notes that no individual protein or multi-protein panel classifier achieved reliable diagnostic discrimination, indicating limited immediate clinical utility.

Provenance

Source

figshare

Collection Method

Unbiased screening using Nucleic Acid Protein Programmable Array (NAPPA) on samples from PANDAS, ASD, and healthy control groups.

Freshness

Last updated 2026-04-29 05:41:44; freshness should be verified.