Vibrio Cholerae Genome Functional Annotation, 2000-2026 Comparison

Over 3500 protein-coding genes from the Vibrio cholerae O1 El Tor str. N16961 reference genome are compared across functional annotations from 2000 and 2026. The classification of genes as 'hypothetical protein' dropped from over 40% to ~5.7% over this period, with potential roles identified for ~38.5% of remaining hypotheticals. Author Ravipaul Singh provides this updated analysis as an Excel resource on figshare under a CC-BY-4.0 license.

Use Cases

• Track progress in genome annotation over time based on the comparison of 2000 and 2026 data.
• Identify potential functions for hypothetical proteins based on the protein-protein blast comparisons mentioned.
• Study the functional landscape of the Vibrio cholerae genome based on the annotation of its two chromosomes.
• Use the dataset as a reference for comparative genomics studies of bacterial pathogens.

Strengths

• Direct comparison of functional annotations for the same genome across a ~26-year period.
• Focus on a specific, well-studied bacterial strain (V. cholerae O1 El Tor str. N16961).
• Provides potential functional roles for a significant portion (~38.5%) of remaining hypothetical proteins.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (19.6 KB), indicating limited scope.

Provenance

Source

figshare, author Ravipaul Singh.

Collection Method

Comparative analysis of genomic sequencing data and protein-protein blast comparisons.

Time Range

Comparative analysis spans from 2000 to 2026.

Freshness

Last updated 2026-05-19 05:44:48; freshness should be verified.