XIST Expression and X-Chromosome Hypermethylation in Male SLE Patients

720 Systemic Lupus Erythematosus (SLE) patients and 84 healthy controls contributed epigenomic, transcriptomic, and proteomic data from whole blood. The dataset, authored by Helen O. Masson and last updated in April 2026, focuses on the aberrant expression of the XIST long non-coding RNA and X-chromosome hypermethylation in males with SLE.

Use Cases

• Identify sex-specific molecular signatures in SLE based on multi-omic data mentioned in the description
• Investigate the correlation between XIST expression and disease severity in male SLE patients as described
• Analyze patterns of X-chromosome hypermethylation and gene silencing in an autoimmune context

Strengths

• Data from 804 total subjects (720 patients, 84 controls) provides a substantial cohort for analysis
• Multi-omic data includes epigenomic, transcriptomic, and proteomic modalities
• Analysis includes factorial design for disease/control and sex interaction effects

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small at 29.2 KB, indicating limited scope

Provenance

Source

figshare, author Helen O. Masson

Collection Method

Multi-omic analysis of whole blood from SLE patients and healthy controls using a factorial design for differential expression.

Time Range

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Freshness

Last updated 2026-04-09 08:48:14

Geography

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