ZFP36L1 and Autophagy in Murine Norovirus Replication: Experimental Results

Malabika Bhowmik published a study on figshare in April 2026 investigating the antiviral role of the RNA-binding protein ZFP36L1 against murine norovirus 1 (MNV-1). The 58.3 KB PDF describes experimental results showing ZFP36L1 overexpression suppresses viral replication and reduces autophagy-related markers. The work suggests autophagy suppression is a contributing factor to ZFP36L1-mediated norovirus inhibition.

Use Cases

• Study the antiviral mechanisms of ZFP36L1 based on experimental results from murine norovirus infection models.
• Investigate the relationship between autophagy and norovirus replication based on measurements of ATG13, LC3, Beclin-1, and Bcl-2.
• Validate findings on pharmacological modulation of autophagy using rapamycin or 3-methyladenine in the context of viral infection.

Strengths

• The dataset is openly licensed under CC-BY-4.0, permitting broad reuse.
• The description provides specific biological markers and experimental conditions, such as ATG13, LC3-I/II conversion, and the use of rapamycin.

Limitations

• The dataset is a single 58.3 KB PDF file; the underlying raw data tables are not provided separately.
• Row and column counts are unknown, making it impossible to assess the scale of any tabular data within the document.
• The description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from virology and molecular biology research.

Freshness

Last updated 2026-04-21 09:23:42; freshness should be verified.