Table 3_25HC Regulates Macrophage Polarization in Triple-Negative Breast Cancer

A research document from figshare authored by Hongmei Zheng, last updated in May 2026. It presents findings on the role of the oxysterol metabolite 25-hydroxycholesterol in regulating CD163+ macrophage polarization within the tumor immune microenvironment of triple-negative breast cancer. The study integrates multiplex fluorescence immunohistochemistry, bioinformatics, and in vitro/in vivo validation.

Use Cases

• Study the link between lipid metabolism and immune cell function in cancer based on the described 25HC regulatory axis.
• Validate potential therapeutic targets for TNBC based on the identified interferon regulatory factor 7–cholesterol-25-hydroxylase–25HC pathway.
• Analyze the composition of the tumor immune microenvironment in TNBC based on multiplex fluorescence immunohistochemistry data mentioned in the methods.
• Investigate macrophage polarization states in solid tumors based on the focus on CD163+ macrophages.

Strengths

• The dataset is associated with a specific, peer-reviewed research finding on a key regulator (25HC) in TNBC.
• The methodology is described as integrating multiple validation approaches: multiplex fluorescence immunohistochemistry, bioinformatics, and in vitro/in vivo models.
• It is published under a permissive CC-BY-4.0 license, allowing for reuse.

Limitations

• The data is contained within a 7.3 KB DOCX file, indicating it is likely a summary table or document, not a raw dataset.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Multiplex fluorescence immunohistochemistry and bioinformatic analyses, validated with cellular assays and mouse models.

Freshness

Last updated 2026-05-28 04:43:30; freshness should be verified.