PyCryPH2 Protein Knockout Effects on Plasmodium Ookinetes and Sporozoites

A 71.6 KB Excel file from figshare contains experimental data on a novel crystalloid protein in the malaria parasite Plasmodium yoelii. The dataset, authored by Mayumi Tachibana and last updated in May 2026, likely contains results from targeted gene disruption of the pycryph2 gene. It describes the protein's role in crystalloid organelle structure and its impact on sporozoite infectivity in mosquitoes and mice.

Use Cases

• Analyzing the relationship between crystalloid protein structure and sporozoite function based on gene knockout data.
• Comparing infectivity metrics for wild-type versus pycryph2-deficient parasites based on salivary gland invasion and liver infection assays.
• Investigating the role of pleckstrin homology domain proteins in Plasmodium organelle formation based on crystalloid microstructure analysis.

Strengths

• Dataset is focused on a specific, novel protein (PyCryPH2) with a defined functional domain (pleckstrin homology).
• The description provides a clear biological narrative linking gene disruption to observable phenotypes in crystalloid structure and parasite infectivity.
• The file is small (71.6 KB), facilitating quick download and inspection.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's scale is limited to a single protein study in one parasite species (Plasmodium yoelii).

Provenance

Source

figshare

Collection Method

Likely contains experimental data from targeted gene disruption and phenotypic analysis in a malaria parasite model.

Freshness

Last updated 2026-05-18 05:53:47; freshness should be verified.