Gene Expression Patterns Modulated by Tuberculous Exosomal miRNAs in Lung Cancer

Five differentially expressed miRNAs (DEMs) and 54 differentially expressed genes (DEGs) were identified from an analysis of tuberculous pleural effusion-derived exosomes and lung cancer xenografts. The dataset, created by Goeun Park and last updated on 2026-05-28, provides a regulatory network linking TB-associated miRNAs to cancer-related genes like NDUFA4, RPS27, and COX7A2. It is a small, 9.6 KB Excel file shared under a CC-BY-4.0 license on figshare.

Use Cases

• Constructing miRNA-mRNA regulatory networks based on the identified 5 DEMs and 54 DEGs.
• Performing pathway enrichment analysis based on terms like oxidative phosphorylation and ribosome biogenesis mentioned in the results.
• Validating in silico findings from the network analysis using the cancer-related genes NDUFA4, RPS27, and COX7A2.
• Exploring potential biomarkers for TB-associated lung cancer based on the exosomal miRNA profiles described.

Strengths

• The dataset is derived from a described experimental model involving patient-derived exosomes and lung cancer xenograft mice.
• Specific counts of identified regulators are provided: 5 DEMs and 54 DEGs.
• Results include validated cancer-related genes (NDUFA4, RPS27, COX7A2) from in vitro assays.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small at 9.6 KB, indicating limited scope.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Goeun Park.

Collection Method

Exosomes were isolated from tuberculous pleural effusions and injected into lung cancer xenograft mice; differential expression analysis and network modeling were performed.

Freshness

Last updated 2026-05-28 22:03:25; freshness should be verified.