Plasma Exosomal Proteins for Intrahepatic Cholestasis of Pregnancy

SWATH proteomics identified 109 and 46 differentially expressed proteins in plasma exosomes from pregnant women with intrahepatic cholestasis. The dataset likely contains quantitative proteomic profiles from 35 pregnant women, including 10 moderate ICP, 10 severe ICP, and 15 healthy controls. Author Yuxuan Jiang published the data on figshare under a CC-BY-4.0 license.

Use Cases

• Identify diagnostic protein biomarkers for ICP severity based on differential expression in total and placenta-derived exosomes.
• Investigate disease pathology pathways based on bioinformatics analysis of proteins involved in complement activation and coagulation.
• Validate candidate hub proteins like HRG, VWF, and PIGR using the quantitative proteomic profiles.
• Explore the relationship between maternal bile acids and fetal stress response using the proteomic data.

Strengths

• Proteomic profiles from 35 patient samples, providing a basis for comparative analysis.
• Identifies 109 and 46 differentially expressed proteins in two exosome types, offering specific targets.
• Includes samples stratified by disease severity (moderate and severe ICP) and healthy controls.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 33.8 KB, indicating a very limited scope likely focused on summary results rather than raw data.

Provenance

Source

figshare

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:48; freshness should be verified.