Prostate Cancer APTw MRI Biomarkers and Gleason Score Correlation

Featuring quantitative results from a study of 160 patients (86 with prostate cancer, 74 with benign prostatic hyperplasia) who underwent 3.0T multi-parametric MRI. It compares amide proton transfer-weighted (APTw) imaging values with Apparent Diffusion Coefficient (ADC) values, PI-RADS v2.1 scores, and Gleason Scores (GS). The data supports analyses of diagnostic performance for differentiating cancer from hyperplasia and assessing tumor aggressiveness.

Use Cases

• Evaluate the correlation between APTw values and Gleason Score (GS) for prostate cancer risk stratification.
• Compare the diagnostic performance of APTw imaging versus PI-RADS v2.1 scores for differentiating prostate cancer from benign prostatic hyperplasia.
• Analyze APTw values in the PSA 'gray zone' (4–10 ng/mL) to assess utility in challenging diagnostic scenarios.
• Assess the ability of APTw values to differentiate high-risk (GS ≥ 8) from low- and intermediate-risk prostate cancer.

Strengths

• Data is derived from a study of 160 patients, providing a specific clinical cohort size.
• Includes results for challenging subgroups like the PSA 'gray zone' and Transition Zone lesions.
• Quantitative results include specific statistical metrics like AUC values (e.g., 0.915 for a combined model) and correlation coefficients (Spearman’s ρ = 0.407).

Limitations

• The dataset is small at 9.2 KB, indicating limited scope and likely summary statistics rather than raw patient-level data.
• As a retrospective study, the data may have inherent selection biases.
• Specific column names and row counts are unknown, limiting understanding of the data structure.

Provenance

Source

Author Jie Feng via figshare.

Collection Method

Retrospective study analyzing quantitative APTw MRI, ADC values, PI-RADS v2.1 scores, and Gleason Scores from 160 patients.

Freshness

Last updated on 2026-03-20.