Table 3_Association between circulating biomarkers of one-carbon metabolism and glymphatic

A dataset of 210 participants investigates links between one-carbon metabolism biomarkers and glymphatic system function in Alzheimer's disease. It includes serum folate, vitamin B12, homocysteine levels, DTI-ALPS index neuroimaging data, and neuropsychological assessments for normal cognition, mild cognitive impairment, and dementia groups. The data was published by Yali Chen on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Analyze correlations between serum folate levels and glymphatic function based on the DTI-ALPS index
• Compare cognitive performance across biomarker-defined risk groups based on folate and DTI-ALPS index combinations
• Investigate subgroup differences in biomarker associations based on sex and age as described in the results

Strengths

• Includes data from 210 participants across three clinical groups: normal cognition, mild cognitive impairment due to AD, and dementia due to AD
• Combines multiple data types: circulating biomarker measurements (folate, B12, homocysteine), neuroimaging-derived DTI-ALPS index, and comprehensive neuropsychological assessments
• Provides specific statistical results, such as correlation coefficients (r=0.212) and p-values for key associations

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 14.1 KB file size suggests the dataset is very small, potentially containing only summary statistics rather than raw participant-level data

Provenance

Source

Yali Chen via figshare

Collection Method

Clinical study enrolling 210 participants with measurements of circulating biomarkers, neuroimaging, and neuropsychological assessments.

Freshness

Last updated 2026-05-11 04:29:13; freshness should be verified