Meta-Analysis Results on Frailty and Postoperative Delirium After TAVR

A meta-analysis by Zhiheng Liu, published on figshare in May 2026, synthesizes evidence from 10 cohort studies involving 7,702 patients. The analysis quantifies the association between preprocedural frailty and postoperative delirium following transcatheter aortic valve replacement (TAVR). It reports pooled odds ratios and explores heterogeneity across study subgroups.

Use Cases

• Validate the association between frailty and delirium risk based on the pooled odds ratio of 2.17.
• Assess heterogeneity in study findings based on reported subgroup analyses by sample size and diagnostic method.
• Inform clinical risk stratification protocols using the reported prevalence of frailty (26.8%) and POD (10.2%) in the TAVR population.

Strengths

• Includes results from 10 studies with a total of 7,702 patients, providing a substantial evidence base.
• Reports specific statistical results, including a pooled odds ratio of 2.17 with a 95% CI of 1.60–2.95.
• Conducts detailed subgroup and meta-regression analyses to explore sources of heterogeneity.

Limitations

• The dataset is a 22.4 KB document (DOCX) containing summary results, not the underlying patient-level data.
• Row count and column-level documentation for the source studies are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Systematic search and meta-analysis of published cohort studies from PubMed, Embase, and Web of Science.

Time Range

Literature search from database inception to January 22, 2026.

Freshness

Last updated 2026-05-21 05:42:26; freshness should be verified.

Geography

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