Physical Activity and Inflammatory Bowel Disease Risk in UK Biobank Cohort

293,578 UK Biobank participants were tracked to assess the relationship between physical activity intensity and the incidence of Crohn's disease and ulcerative colitis. Author Yitian Wei published this prospective cohort study, which found a protective effect of higher activity against Crohn's disease and a more nuanced link with ulcerative colitis. The dataset was last updated in May 2026.

Use Cases

• Train risk prediction models based on self-reported physical activity levels.
• Analyze non-linear dose-response relationships between activity intensity and disease incidence using restricted cubic spline methods.
• Investigate differential effects of physical activity on Crohn's disease versus ulcerative colitis.
• Validate public health recommendations for physical activity in the context of inflammatory bowel disease prevention.

Strengths

• Large prospective cohort of 293,578 participants from the UK Biobank.
• Incident cases were identified through linked hospital admission and death registry records, suggesting high-quality outcome ascertainment.
• Analysis employed multivariable Cox regression and restricted cubic splines to model complex associations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic and demographic biases inherent to the UK Biobank source.

Provenance

Source

UK Biobank

Collection Method

Prospective cohort study analyzing self-reported physical activity and linked health records.

Freshness

Last updated 2026-05-14 05:42:13; freshness should be verified.

Geography

United Kingdom