Serum Active IL-18 Levels in Adult-Onset Still's Disease with Clinical Correlations

A 2026 study by Shuhei Yoshida presents clinical data from 47 untreated patients with adult-onset Still's disease (AOSD), 42 with rheumatoid arthritis, 9 with familial Mediterranean fever, and 26 healthy controls. The dataset likely contains measurements of serum active IL-18, 69 other cytokines, and clinical parameters like Pouchot score, ferritin, and C-reactive protein. It was published on figshare under a CC-BY-4.0 license.

Use Cases

• Evaluate the diagnostic accuracy of active IL-18 for AOSD based on the reported sensitivity and specificity.
• Analyze correlations between active IL-18 levels and clinical features like rash and splenomegaly mentioned in the description.
• Investigate relationships between inflammasome activity and other cytokines, such as macrophage colony-stimulating factor and IL-12 (p40).
• Assess changes in biomarker levels following immunosuppressive therapy as indicated in the results.

Strengths

• Includes a defined cohort of 124 total subjects across disease and control groups.
• Reports specific statistical results, including a diagnostic cutoff of >4,231.1 pg/mL with 89.4% sensitivity and 92.9% specificity.
• Correlates biomarker levels with multiple clinical scores and parameters like the HScore and serum ferritin.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 15.8 KB, indicating limited scope.
• Data may reflect bias inherent to the specific patient cohort studied.

Provenance

Source

figshare

Collection Method

Serum samples were analyzed using specific ELISA and multiplex suspension array techniques.

Freshness

Last updated 2026-04-28 05:24:14; freshness should be verified.