Table 3_Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric

A bioinformatics and clinical study analyzing the association between NDRG4 gene methylation in peripheral blood leukocytes and gastric cancer risk, chemotherapy efficacy, and patient prognosis. The work includes analysis of TCGA and GEO databases and a two-phase case-control study involving 310 gastric cancer patients and 300 controls. The dataset was authored by Zhan Li and last updated on 2026-04-27.

Use Cases

• Assessing gastric cancer risk based on methylation levels at specific NDRG4 CpG sites mentioned in the description
• Evaluating chemotherapy efficacy in gastric cancer patients using methylation data from peripheral blood leukocytes
• Predicting progression-free survival (PFS) in gastric cancer patients based on NDRG4-chr16:58497239 methylation status
• Investigating the relationship between rs7202037 SNP genotypes and NDRG4 gene methylation levels

Strengths

• Includes data from a two-phase case-control study with 310 gastric cancer patients and 300 controls
• Analyzes specific CpG sites (NDRG4-chr16:58497239 and NDRG4-chr16:58497262) with reported odds ratios and confidence intervals
• Integrates bioinformatics analysis from TCGA and GEO databases with clinical validation

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (20.0 KB), suggesting limited scope or summary-level data

Provenance

Source

figshare, authored by Zhan Li

Collection Method

Bioinformatics analysis of TCGA and GEO databases combined with a two-phase case-control study

Freshness

Last updated 2026-04-27 04:12:21; freshness should be verified