Bioinformatics Analysis of Bushen Anzhi Recipe for Aging-Related Insomnia

342 insomnia and 213 control samples from the GSE98582 dataset were analyzed alongside 931 neuroinflammatory targets and 25 active herbal components. The dataset contains results from multi-level network and enrichment analyses identifying core target genes like HIF1A, PTGS2, and GSK3B. Author Haiming Li published the data on figshare under a CC-BY-4.0 license, last updated on 2026-05-08.

Use Cases

• Validate gene expression targets for insomnia treatments based on the 16 identified neuroinflammation and drug target-related differentially expressed genes.
• Analyze multi-level interaction networks for herbal compounds based on the 25 effective components and core targets mentioned.
• Investigate the Wnt signaling pathway's role in insomnia based on the described changes in GSK-3β, β-catenin, and Wnt3a levels.
• Reproduce bioinformatics screening workflows for neuroinflammatory targets using the referenced GeneCards and MSigDB databases.

Strengths

• Includes data from 555 total samples (342 insomnia, 213 control) from a publicly available GEO dataset.
• Analysis is based on 931 identified neuroinflammatory targets and 25 active herbal components.
• Results are supported by in-vivo rat model experiments with three groups of 20 rats each.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 12.3 KB, indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

Gene Expression Omnibus (GEO) dataset GSE98582, Traditional Chinese Medicine Systems Pharmacology and HERB databases.

Collection Method

Bioinformatics analysis of gene expression data, network analysis via STRING, MSigDB, and GeneMANIA, and validation via rat model experiments.

Time Range

The experimental timeframe is not specified in the description.

Freshness

Last updated 2026-05-08 05:54:40; freshness should be verified.

Geography

The geographic origin of the data or samples is not specified.