PP1 Analogs: Cellular Effects on Non-Tumoral and Tumoral Cell Lines

A dataset from figshare by Coralie Gicquel, last updated in April 2026, examines the cellular effects of five bulky PP1 analog inhibitors. The 11.5 KB Excel file likely contains measurements from experiments on cell migration, invasion, proliferation, cell cycle, viability, and differentiation. The work investigates the specificity of these inhibitors at concentrations as low as 2 µM.

Use Cases

• Assessing inhibitor specificity for analog-sensitive kinases based on described cellular assays.
• Comparing the effects of different PP1 analogs (1NA-, 1NM-, 3MB-, 3IB-, 3MSB-PP1) on cell viability and proliferation.
• Evaluating non-specific cellular effects of kinase inhibitors at concentrations ≥5 µM or 2 µM as mentioned in the description.
• Identifying suitable inhibitor concentrations for minimal off-target effects in cellular studies.

Strengths

• Dataset is small (11.5 KB), facilitating quick download and inspection.
• License is CC-BY-4.0, permitting broad reuse with attribution.
• Description provides specific experimental context, including five tested inhibitors and six measured cellular processes.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Sample data is unavailable, preventing preview of data structure and values.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from in vitro cellular assays described in the associated research.

Freshness

Last updated 2026-04-28 10:21:03; freshness should be verified.