Table 3_Bushen Huoxue recipe restores trophoblast proliferation through the PI3K/AKT pathw

A research document details a study on the molecular mechanisms of Bushen Huoxue Recipe (BSHXR) for treating recurrent spontaneous abortion (RSA). The work includes UPLC–Q–TOF–MS/MS analysis identifying 155 chemical constituents, transcriptome sequencing, network pharmacology identifying 267 therapeutic targets, and in vivo mouse model experiments. The dataset was authored by Jingheng You and uploaded to figshare on 2026-04-21.

Use Cases

• Validate network pharmacology predictions for BSHXR's 267 therapeutic targets against RSA.
• Analyze transcriptomic data to explore the role of the PI3K/AKT pathway in trophoblast proliferation.
• Correlate identified chemical constituents from UPLC–Q–TOF–MS/MS with in vivo efficacy metrics like embryo loss rate.
• Study the relationship between serum progesterone (P) and chorionic gonadotropin (CG) levels and placental tissue morphology in an RSA mouse model.

Strengths

• The study identifies 155 chemical constituents of the BSHXR formula.
• Network pharmacology analysis identified 267 potential therapeutic targets for RSA.
• In vivo results show a statistically significant reduction in embryonic loss rate (p < 0.01) and increased serum hormone levels (p < 0.05) in the treatment group.

Limitations

• The primary data file is a 2.1 MB DOCX document; underlying raw data files (e.g., sequencing reads, raw spectra) are not specified.
• Row count and column-level documentation for any potential structured data are unknown.
• The dataset's freshness should be verified as the last update date is in the future (2026-04-21).

Provenance

Source

figshare, author Jingheng You

Collection Method

Experimental study using UPLC–Q–TOF–MS/MS, transcriptome sequencing, network pharmacology, and a mouse miscarriage model.

Freshness

Last updated 2026-04-21 05:36:19