Case Report: A 47-Year Clinical Course of Tonsillar Adenoid Cystic Carcinoma

A single, detailed case report documents one of the longest known survivals for tonsillar adenoid cystic carcinoma, spanning 47 years from diagnosis in 1977 to death in 2024. The report includes a timeline of clinical interventions and molecular profiling data from a 2018 recurrence. Mingzhu Wang authored this CC-BY-4.0 licensed document, last updated on figshare in June 2026.

Use Cases

• Study the natural history and indolent phases of rare head and neck cancers based on the detailed 47-year timeline.
• Analyze treatment patterns and outcomes for adenoid cystic carcinoma based on the described surgical, radiation, and chemoradiotherapy interventions.
• Investigate molecular markers like NOTCH2 copy number gain in late-stage progression based on the genomic analysis mentioned.
• Inform long-term surveillance strategies for cancer patients based on the case's demonstration of late metastatic progression.

Strengths

• Provides a uniquely long clinical timeline of 47 years for an extremely rare cancer.
• Includes specific molecular profiling results (NOTCH2, MTOR, SPEN) from a recurrent lesion.
• Document is licensed under CC-BY-4.0, allowing for broad reuse.

Limitations

• The dataset is a single case report (15.1 KB DOCX file), representing an N of 1.
• Row and column structures are unknown; data is embedded in narrative text.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Clinical case documentation and molecular analysis.

Time Range

1977 to 2024

Freshness

Last updated 2026-06-02 04:28:45; freshness should be verified.