Table 3_Case Report: Treatment of refractory lung disease in systemic juvenile idiopathic

A clinical case report document describing two pediatric patients with systemic juvenile idiopathic arthritis-associated lung disease (sJIA-LD). The report details their treatment with cyclophosphamide and rituximab combination therapy, authored by William J. Freeman and last updated in May 2026. The 27.2 KB document is licensed under CC-BY-4.0 and hosted on figshare.

Use Cases

• Analyze clinical outcomes of combination immunosuppressive therapy based on the detailed patient response metrics.
• Study the management of refractory systemic juvenile idiopathic arthritis based on the described escalation from conventional therapies.
• Investigate the relationship between lung disease, pulmonary hypertension, and macrophage activation syndrome in sJIA based on the case descriptions.
• Review specific clinical improvement markers such as oxygen requirement, pulmonary arterial pressure, and height velocity based on the reported results.

Strengths

• Provides specific, quantified clinical outcomes for two patients, including changes in oxygen requirement (4 LPM to 0.5 LPM) and pulmonary arterial pressure (47 to 25 mmHg).
• Focuses on a rare and severe complication (sJIA-LD) where literature and established management strategies are lacking.
• Document is openly licensed (CC-BY-4.0), facilitating reuse and distribution.

Limitations

• Row count is unknown, which may limit suitability assessment; the dataset is a single document of limited scope (27.2 KB).
• Column-level documentation is absent; field semantics must be inferred after download as the data format is a DOCX text document.
• The dataset is a case report of two patients, which limits statistical generalizability.

Provenance

Source

figshare

Collection Method

Clinical case report authored by William J. Freeman.

Time Range

Covers the treatment period for the two described cases; specific dates are not provided.

Freshness

Last updated 2026-05-04 04:24:23; freshness should be verified.

Geography

Geographic origin of the patients or study institution is not specified.