Meta-Analysis of ctDNA Prognostic Value in Resectable Gastric Cancer

Jidong Bian's meta-analysis synthesizes data from 25 studies (60 datasets) on circulating tumor DNA (ctDNA) and survival outcomes in gastric cancer patients undergoing surgery. The analysis includes hazard ratios for overall and disease-free survival, subgroup analyses, and trial sequential analysis. The dataset was last updated on May 18, 2026.

Use Cases

• Validate the prognostic value of ctDNA positivity for overall survival based on the pooled hazard ratio.
• Compare the prognostic strength of pre-operative versus post-operative ctDNA measurements for disease-free survival.
• Assess evidence sufficiency for clinical relevance using the trial sequential analysis results.
• Explore subgroup effects across different detection platforms, sample sources, and regions mentioned in the description.

Strengths

• Includes data from 25 studies and 60 datasets, providing a substantial synthesis.
• Focuses exclusively on resectable gastric cancer, reducing cohort heterogeneity.
• Methodologically rigorous, employing random-effects models, sensitivity analyses, and trial sequential analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Publication bias was present for overall survival, as noted in the results.

Provenance

Source

figshare, author Jidong Bian.

Collection Method

Systematic review and meta-analysis of studies from four major databases.

Time Range

Studies searched up to May 2025.

Freshness

Last updated 2026-05-18 05:41:22; freshness should be verified.