ALDH1L1 Expression and Survival in Hormone Receptor-Positive Breast Cancer

A 2026 study analyzes ALDH1L1 expression in breast cancer using data from Seoul National University Hospital and the METABRIC database. The dataset includes clinical and survival outcomes for over 1,000 invasive ductal carcinoma patients. It was authored by Han Suk Ryu and published on figshare under a CC-BY-4.0 license.

Use Cases

• Identify prognostic biomarkers for hormone receptor-positive breast cancer based on ALDH1L1 expression levels.
• Correlate clinical features like tumor size and lymphatic invasion with molecular expression data.
• Validate subtype-specific survival associations using patient outcome data.
• Investigate potential therapeutic targets by linking in vitro cytotoxicity results to clinical findings.

Strengths

• Includes data from three distinct cohorts totaling 1,086 cases, providing a multi-faceted view.
• Clinical data includes tumor size, grade, lymphatic invasion, lymph node metastasis, and survival outcomes.
• Findings are validated by analysis of the external METABRIC database.

Limitations

• The dataset is described in a 647.2 KB DOCX file; the underlying structured data files are not available, limiting direct analysis.
• Column-level documentation is absent; field semantics must be inferred from the manuscript.
• Row count for the underlying clinical data is unknown, which may limit suitability assessment.

Provenance

Source

Seoul National University Hospital patient cohorts and the METABRIC database.

Collection Method

Immunostaining performed on tissue microarrays and whole section slides; clinical data collected from patient records.

Freshness

Last updated 2026-05-25.

Geography

Seoul, South Korea (primary cohorts).