Neonatal Intraventricular Hemorrhage Microglia Transcriptomics and Iron Accumulation Data

Vanessa Castro Diaz published a study on figshare in 2026 analyzing microglia response to intraventricular hemorrhage in premature rabbit pups. The research describes biochemical and transcriptomic data following combination drug therapy with sulforaphane and deferoxamine. The dataset includes gene expression analysis for targets like S100A8, CXCL10, HMOX1, and ACSL4.

Use Cases

• Analyze microglia phenotype shifts (M1 vs. total IBA-1+) based on transcriptomic data mentioned in the description
• Study gene expression changes in iron metabolism and transport (e.g., TFRC, SLC7A11) following deferoxamine treatment
• Investigate correlations between pro-inflammatory chemokine expression (CXCL8, CXCL10) and tissue iron accumulation after IVH
• Model the effects of Nrf2-ARE pathway activation via sulforaphane on inflammatory gene networks

Strengths

• Dataset includes transcriptomic analysis of multiple specific gene targets (e.g., S100A8, S100A12, CXCL8, CXCL10, HMOX1, ACSL4) as described.
• Research design compares combination therapy (SFN-DFN) and monotherapy (DFN) effects, providing comparative data points.
• License is CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (19.1 KB), suggesting limited scope, likely summary-level results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Likely contains biochemical measurements and transcriptomic analysis from a controlled animal model study of neonatal intraventricular hemorrhage.

Freshness

Last updated 2026-05-25 04:34:45; freshness should be verified.