Meta-Analysis of 50 PCI Trials with 39,863 Patient Outcomes

A network meta-analysis of 50 randomized studies involving 39,863 patients, comparing outcomes of angiography-, physiology-, and imaging-guided percutaneous coronary intervention (PCI). It reports relative risks for clinical endpoints like major adverse cardiovascular events, all-cause mortality, and stent thrombosis across five guidance modalities. The analysis was conducted by Yuancheng Jin and published in 2026.

Use Cases

• Compare relative risk (RR) estimates for major adverse cardiovascular events (MACE) across angiography, FFR, iFR, IVUS, and OCT guidance modalities.
• Rank PCI guidance strategies using SUCRA values based on outcomes like all-cause mortality and cardiac death.
• Analyze the confidence intervals for myocardial infarction and stent thrombosis rates to assess statistical significance between modalities.
• Validate sensitivity analysis results against primary outcome estimates for the 39,863-patient cohort.

Strengths

• Based on 50 randomized studies, providing a substantial evidence base.
• Includes data on 39,863 patients with gender breakdown (29,571 male, 10,031 female).
• Reports specific patient counts per guidance modality (e.g., 15,463 angiography-guided).
• Uses network meta-analysis methodology to compare five distinct PCI strategies.

Limitations

• Data is presented in a DOCX document (80.2 KB), not a structured tabular format, limiting computational analysis.
• The underlying patient-level data from the 50 trials is not included, only aggregated results.
• Sample data and column definitions are unavailable, requiring manual extraction from the report.

Provenance

Source

figshare, author Yuancheng Jin.

Collection Method

Systematic review and network meta-analysis of 50 randomized studies.

Freshness

Last updated March 2026.