ART-Induced Senescence-Like Reprogramming in Alveolar Macrophages

A systems immunology study evaluating the long-term impact of continuous antiretroviral therapy (ART) on alveolar macrophages in people with HIV and on PrEP. The dataset likely contains transcriptomic and epigenetic measurements showing a progressive senescence-like pro-inflammatory state. The data was authored by Vinicius M. Fava and uploaded to figshare in April 2026.

Use Cases

• Analyze transcriptomic priming of senescence genes based on ART duration
• Model gene regulatory networks linking pro-inflammatory transcription factors to ART effects
• Assess interferon signaling impairment in alveolar macrophage response to SARS-CoV-2 challenge

Strengths

• Data is derived from a systems immunology approach, likely integrating multiple measurement types
• The study links ART effects to specific durations of treatment, suggesting a temporal dimension
• The dataset is openly licensed under CC-BY-4.0

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (84.6 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Systems immunology approach evaluating alveolar macrophages from people with HIV and on PrEP

Freshness

Last updated 2026-04-22 05:49:12