Cost-Effectiveness of Single-Dose vs. Two-Dose HPV Vaccination in Kenya and India

A Markov cohort model analysis compares the cost-effectiveness of single-dose and two-dose HPV vaccination schedules in a composite low- and middle-income country setting derived from Kenya and India. The model tracks 100,000 girls aged 9 years over a lifetime horizon, estimating costs, disability-adjusted life years averted, and incremental cost-effectiveness ratios. The dataset was authored by Jinyao Wang and last updated on June 4, 2026.

Use Cases

• Compare cost-effectiveness metrics between single-dose and two-dose HPV vaccination strategies based on the described Markov model outputs.
• Analyze the impact of second-dose dropout rates on vaccination program effectiveness based on scenario analyses ranging from 5% to 45%.
• Evaluate the influence of single-dose protection duration on health outcomes based on scenarios of 10-year, 20-year, and lifetime protection.
• Assess probabilistic uncertainty in cost-effectiveness results based on the 10,000-simulation probabilistic sensitivity analysis.

Strengths

• Model is based on a cohort of 100,000 girls tracked over a lifetime horizon.
• Analysis includes 10,000-simulation probabilistic sensitivity analysis to characterize uncertainty.
• Results are presented for a composite LMIC setting derived from specific country data (Kenya and India).

Limitations

• Dataset is a 25.0 KB DOCX file, suggesting limited scope and likely containing summary tables rather than raw simulation data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The model uses a static direct-effect framework that does not capture herd immunity.

Provenance

Source

figshare

Collection Method

Static Markov cohort modelling analysis.

Time Range

Lifetime horizon simulation from age 9 to 99.

Freshness

Last updated 2026-06-04 05:40:42

Geography

Composite low- and middle-income country setting derived from Kenya and India.