CrpH Protein Data for Bordetella pertussis Heme-Copper Oxidoreductase Function

Majda Hachmi published a dataset on figshare in March 2026, analyzing the CrpH protein in Bordetella pertussis. The 4.9 MB dataset supports findings that CrpH, a PepSY_TM family protein, contributes to bacterial fitness and enhances respiration by heme-copper oxidoreductases. The work involved in vitro and in vivo experiments, transcriptomics, and in silico analyses to define a new subfamily of these proteins.

Use Cases

• Comparative genomic analysis based on the identification of CrpH orthologs across bacterial species.
• Studying protein function in heme-copper oxidoreductase assembly based on the synthetic phenotype with a copper reductase mutant.
• Investigating bacterial responses to copper starvation based on the described upregulation of CrpH expression.
• Characterizing heme-binding motifs in membrane-associated enzymes based on the PepSY_TM superfamily classification.

Strengths

• Dataset is 4.9 MB, indicating a focused and manageable size for analysis.
• Published under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• Includes in silico analyses identifying thousands of CrpH orthologs, suggesting a broad comparative context.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Data generated from in vitro and in vivo experiments, transcriptomics, and in silico analyses as described in the associated study.

Freshness

Last updated 2026-03-18 06:42:30; freshness should be verified.