DNER in Renal Cell Carcinoma: Glycolytic Reprogramming and JAK2/STAT3 Signaling

A research document details the role of the DNER gene in clear cell renal cell carcinoma progression. The study integrates bioinformatic screening with in vitro and in vivo experiments to identify DNER as a hub gene linking metabolism and immune infiltration. Author Anrui Li published the 132.2 KB document under a CC-BY-4.0 license on figshare in May 2026.

Use Cases

• Identify metabolic pathway genes correlated with patient prognosis based on the bioinformatic screening described.
• Study the link between tumor cell glycolysis and immunosuppressive microenvironment formation based on the described DNER-driven signaling cascade.
• Investigate potential synthetic lethality with PARP inhibitors based on the preliminary evidence of DNER overexpression and Olaparib sensitivity mentioned.

Strengths

• The description provides a detailed mechanistic model linking DNER to the JAK2/STAT3 pathway and glycolytic enzymes LDHA and PKM.
• The document is openly licensed under CC-BY-4.0, permitting reuse and redistribution.

Limitations

• The dataset is a 132.2 KB DOCX file, indicating a very limited scope, likely a single research table or summary.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Anrui Li.

Collection Method

Likely contains results from integrated bioinformatic analyses and experimental validation as described.

Freshness

Last updated 2026-05-22 06:09:51; freshness should be verified.