Meta-Analysis of Probiotic Effects on Diabetic Kidney Disease from 11 RCTs

A 2026 systematic review and meta-analysis by Zhi-Qing Huang, aggregating results from 11 randomized controlled trials involving 726 participants. The study evaluates the efficacy of probiotic supplementation on renal function, metabolic, inflammatory, and oxidative stress markers in patients with diabetic kidney disease. The document is a CC-BY-4.0 licensed summary of the analysis, published on figshare.

Use Cases

• Assessing the impact of probiotics on serum creatinine and estimated glomerular filtration rate based on the reported meta-analysis results.
• Evaluating probiotic effects on glycemic control parameters like fasting plasma glucose and glycated hemoglobin as described in the findings.
• Analyzing changes in inflammatory markers such as high-sensitivity C-reactive protein and oxidative stress indicators like malondialdehyde from the aggregated trial data.
• Reviewing methodological approaches for systematic reviews and meta-analyses in clinical nutrition based on the described search and analysis process.

Strengths

• Includes quantitative results from 11 randomized controlled trials, a standard for clinical evidence.
• Reports specific effect sizes (e.g., MD -0.17 for serum creatinine) and confidence intervals for multiple outcome measures.
• Uses a defined and transparent methodology, including searches across seven databases and the Cochrane Risk of Bias tool.

Limitations

• The dataset is a 136.2 KB summary document (DOCX), not the underlying raw trial data, limiting direct analysis.
• Row count and column-level documentation for any underlying data tables are unknown.
• The clinical efficacy and long-term effects noted in the conclusion require further validation in large-scale studies.

Provenance

Source

Zhi-Qing Huang via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled trials identified from seven databases (PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, SinoMed).

Time Range

Studies published from database inception to July 2025.

Freshness

Last updated 2026-05-20 05:44:20.

Geography

null