Oropouche Virus Virulence Data in AG129 Mouse Model

Experimental data compares virulence and neuroinvasion of historical and contemporary Oropouche virus strains in the AG129 mouse model. The dataset likely contains measurements of viremia, viral loads across organs, mortality rates, and cytokine responses. It was authored by Ellen Caroline Nobre Santos and uploaded to figshare on May 19, 2026.

Use Cases

• Compare virulence metrics between historical and reassortant virus strains based on mortality and disease progression data.
• Analyze viral dissemination patterns based on organ-specific viral load measurements.
• Investigate inflammatory response to infection based on cytokine upregulation data.
• Model the relationship between viral evolution and clinical severity based on experimental outcomes.

Strengths

• Data compares two distinct 2024 reassortant isolates (OROV_SC2024 and OROV_AC2024) against a historical prototype.
• Includes measurements across multiple organs (spleen, kidney, liver, lung, uterus, testes, brain).
• Published under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to a specific mouse model (AG129), which may not fully represent human infection.

Provenance

Source

figshare

Collection Method

Experimental data from a virology study.

Time Range

Data includes contemporary isolates from 2024 and a historical prototype.

Freshness

Last updated 2026-05-19 05:41:53; freshness should be verified.

Geography

Isolates from non-Amazonian and Amazon Basin regions in South America.