Systematic Review and Meta-Analysis on Endocrine Disruptors and Endometrial Cancer Risk

A systematic review and meta-analysis by Lutian Gong, published on figshare in 2026, evaluates the relationship between environmental endocrine-disrupting chemicals and endometrial cancer risk. It includes 14 studies published up to November 30, 2025, with quantitative meta-analyses for cadmium and polychlorinated biphenyls (PCBs). The work also provides a narrative review of evidence on PFAS, phthalates, and bisphenols.

Use Cases

• Assess the association between cadmium exposure and endometrial cancer risk based on the reported meta-analysis results.
• Evaluate the evidence for polychlorinated biphenyls (PCBs) as a risk factor for endometrial cancer based on the reported meta-analysis.
• Review the current state of evidence on emerging endocrine disruptors like PFAS, phthalates, and bisphenols in relation to endometrial cancer.
• Identify gaps in the literature on environmental chemicals and cancer to inform future study designs.

Strengths

• Includes a meta-analysis of 14 studies with specific risk ratios and confidence intervals reported.
• Provides subgroup analyses for factors like menopausal status and hormone therapy.
• Uses a structured narrative review to summarize evidence on PFAS, phthalates, and bisphenols.

Limitations

• The dataset is a 27.5 KB DOC file, indicating it is likely a summary document rather than raw data.
• Row count and column-level documentation are absent; data structure must be inferred from the text.
• Quantitative synthesis was not feasible for PFAS, phthalates, or bisphenols due to a limited number of studies.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, EMBASE, and Cochrane Library.

Time Range

Studies published up to November 30, 2025.

Freshness

Last updated 2026-05-28 04:51:55; includes studies up to November 30, 2025.