E. coli Urinary Tract Infection Model in Göttingen Minipigs

A 2026 study by Joyce Lübbers describes a novel intraurethral infection model using uropathogenic E. coli strain UTI89 in Göttingen minipigs. The model established infection for 14 days and recovered bacteria were characterized via agglutination and whole genome sequencing. The results emphasize the need for strain identity verification in UTI model studies.

Use Cases

• Evaluating vaccine efficacy against uropathogenic E. coli based on the described intraurethral challenge model
• Testing antibiotic treatment outcomes in a minipig UTI model based on bacterial enumeration from urine
• Studying strain persistence and identity verification in animal infection models based on agglutination and sequencing results

Strengths

• The model successfully established infection for 14 days, providing a defined infection window
• Strain identity was verified for 75% of animals, providing a measure of model fidelity
• The dataset is openly licensed under CC-BY-4.0

Limitations

• The dataset is a 34.7 KB DOCX file, suggesting limited scope and likely containing textual results rather than raw data tables
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Intraurethral challenge with UPEC strain UTI89 in minipigs, followed by bacterial enumeration from urine and strain characterization.

Freshness

Last updated 2026-05-18 05:45:00