Influenza A(H1N1) Evolutionary Trajectory and Co-Detection Analysis (2000-2025)

11,848 unique publications were analyzed to map the evolutionary dynamics and reported co-detections of human influenza A(H1N1) from 2000 to 2025. The study integrates bibliometric analysis, expert-guided curation, and sequence data, including GenBank-derived hemagglutinin sequences. It was authored by Xinrui Cao and published on figshare in March 2026.

Use Cases

• Analyze the post-2010 shift in the hemagglutinin mutational landscape, focusing on recurrent substitutions at sites like S13, S146, S160, and S202.
• Map literature-derived co-detection records to identify frequently reported co-pathogens such as RSV and SARS-CoV-2 across studies.
• Examine the conformationally flexible hemagglutinin segment spanning residues aa190–aa226 for insights into the receptor-binding microenvironment.
• Investigate the G219A mutation in Eurasian avian-like H1N1 strains as a hypothesis-generating site of interest within the receptor-binding region.

Strengths

• Integrates 11,848 unique publications from PubMed, Web of Science, and Scopus, providing a broad evidence base.
• Covers a 25-year time range (2000–2025) for longitudinal analysis of viral evolution.
• Combines bibliometric data with expert-guided curation and sequence/structure analysis from GenBank and Swiss-Model.

Limitations

• Co-detection records reflect heterogeneous reporting composition across studies, not population-level prevalence.
• The 1.7 MB file size indicates a small, likely summary-level dataset, not raw sequence or publication records.
• Findings, such as the prioritized G219A mutation, are described as hypothesis-generating rather than algorithm-derived global signals.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis (15,028 retrieved records), expert-guided curation, and sequence/structure-informed interpretation using GenBank and Swiss-Model.

Time Range

2000–2025

Freshness

Last updated March 2026, providing recent synthesis.

Geography

Global scope with a specific China-focused module for certain strain analysis.