Meta-Analysis of Febuxostat Effects on Renal Transplant Recipients with Hyperuricemia

A meta-analysis of studies up to October 17, 2024, synthesizing evidence on febuxostat's effects on uric acid and renal function. Sheng Chao authored this work, which reports a mean difference of -129.981 μmol/L in uric acid levels and a -1.878 mL/min/1.73 m² change in eGFR. The dataset is a 17.7 KB DOCX file containing the analysis results.

Use Cases

• Assess the efficacy of febuxostat in lowering uric acid levels based on reported mean differences.
• Evaluate changes in renal function markers like creatinine and eGFR after febuxostat administration.
• Analyze the impact of febuxostat on other biochemical indices such as hemoglobin, white blood cells, and liver enzymes.
• Conduct sensitivity analyses on meta-analysis findings for robustness checks.

Strengths

• Includes a systematic review registration (PROSPERO CRD420261300034) for transparency.
• Reports specific statistical results, including a mean difference of -129.981 μmol/L for uric acid reduction.
• The analysis searched multiple databases including Web of Science, PubMed, and the Cochrane Library.

Limitations

• The dataset is very small at 17.7 KB, indicating limited raw data scope.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description is a meta-analysis summary; the underlying study data is not directly provided.

Provenance

Source

figshare, author Sheng Chao.

Collection Method

Systematic review and meta-analysis of studies from Web of Science, PubMed, Cochrane Library, Wan Fang, and CNKI.

Time Range

Studies searched up to 17 October 2024.

Freshness

Last updated 2026-03-17 13:04:41; freshness should be verified.