Phthalate Exposure and Diabetic Retinopathy Risk Factors

This dataset from figshare contains clinical and environmental data exploring associations between phthalate exposure and diabetic retinopathy (DR). It includes NHANES survey data (2017-2018) and an independent clinical cohort, analyzed via multiple feature-selection methods, network toxicology, and molecular docking. Key findings link outdoor time, serum vitamin D, electronic device use, cataracts, and urinary phthalates to DR odds. Thedataset supports research into environmental chemical contributions to eye disease.

Use Cases

• Analyze associations between urinary phthal ate biomarkers และ clinical DR outcomes using logistic regression
• Perform network toxicology analysis on overlapping target genes identified from molecular docking
• Validate molecular docking predictions of MiBP binding to SRC, BCL2, และ MAPK1 with experimental assays

Strengths

• Integrates multiple data sources (NHANES survey และ independent clinical cohort)
• Applies multi-modal analysis (feature selection, network toxicology, molecular docking)
• Identifies novel clinical correlates (outdoor time, vitamin D, device use, cataract) with specific ORs และ CIs reported

Limitations

• Dataset size small (26.8 KB DOCX file) suggests limited raw data inclusion
• Column details unknown — requires inspection after download to assess feature granularity
• Freshness unclear — last updated 2026-05-13 but underlying NHANES data may be older

Provenance

Source

figshare (academic repository)

Collection Method

Collected from NHANES public survey และ an independent clinical cohort

Time Range

NHANES data covers 2017–2018;clinical cohort collection date unspecified

Geography

Likely United States (NHANES) but unspecified for clinical cohort