Herpes Zoster Pain Outcomes Predicted by VZV Genotypes and gE Mutations

52 herpes zoster patients from Chongqing were sequenced to analyze varicella-zoster virus genotypes and glycoprotein E mutations. The study developed a predictive model for pain relief outcomes with an AUC of 0.87, integrating viral genetic features with host immunological markers. Ying Shi published this research dataset on figshare under a CC-BY-4.0 license.

Use Cases

• Predicting poor pain relief outcomes in herpes zoster patients based on VZV genotype and gE mutation patterns.
• Analyzing associations between specific gE mutations (e.g., T→I substitution at positions 250–291) and immunological markers like gE antigen and antibody levels.
• Investigating the distribution of VZV genotypes (Clade 2, 3, 4, 1, 5) within a regional patient cohort.
• Building L1-regularized regression models for clinical stratification using integrated viral genotypic and host immune response data.

Strengths

• Includes sequenced data from 46 patient samples, providing a foundation for genetic analysis.
• The predictive model for pain outcomes demonstrated good performance with an AUC of 0.87 and a PR-AUC of 0.74.
• Integrates multiple data types: viral genotype, specific gene mutations, and clinical immunological indicators.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (14.7 KB), indicating limited scope and sample size.

Provenance

Source

Ying Shi

Collection Method

VZV genotyping via SNP analysis of ORF22 region and gE gene mutation analysis via PCR and sequencing from 52 HZ outpatients.

Freshness

Last updated 2026-04-29 05:58:11; freshness should be verified.

Geography

Chongqing, China