Rat Study Data on L-Se-methylselenocysteine Effects on Gut Microbiota and Toxicity

A 90-day chronic toxicity study on Sprague–Dawley rats conducted by Hui Zhang, with data last updated in March 2026. The dataset likely contains results from integrated intestinal microbiome and metabolome analysis exploring the effects of L-Se-methylselenocysteine. It includes findings on dose-dependent health benefits and gender-specific hepatosplenic injury at high doses.

Use Cases

• Analyze dose-dependent effects on gut microbiota biodiversity based on the described 0.25–2.25 mg/kg bw/day dosing
• Investigate gender-specific toxicity responses based on the described hepatosplenic injury in female rats
• Study correlations between probiotic abundance and beneficial metabolite synthesis based on the gut microbiota-metabolite axis concept
• Evaluate hematological and serum biochemical indices changes based on the described amelioration

Strengths

• Data is from a 90-day chronic toxicity study, providing longitudinal insights
• Includes integrated microbiome and metabolome analysis, suggesting multi-modal data
• Explicitly defines a safe dosage range (0.25–0.75 mg/kg bw/day) and a toxic high dose (2.25 mg/kg bw/day)
• License is CC-BY-4.0, allowing open reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset size is 14.0 KB, indicating a very limited scope of data

Provenance

Source

figshare

Collection Method

Data likely originates from a laboratory study on Sprague–Dawley rats, as described.

Time Range

Study duration was 90 days.

Freshness

Last updated 2026-03-19 14:03:06; freshness should be verified