Gene Expression Analysis of lncRNAs in Primary Sjögren's Syndrome

92 patient and 34 control samples from minor salivary glands were analyzed via deep stranded total transcriptome sequencing. The dataset contains results from a genome-wide competing endogenous RNA network analysis, identifying 3,035 lncRNAs and 10,838 coding genes. It was authored by Zhongshan Li and last updated on 2026-04 15.

Use Cases

• Constructing competing endogenous RNA networks based on shared miRNA binding sites and gene expression correlations.
• Identifying differentially expressed long non-coding RNAs between patient and control groups.
• Investigating the regulatory roles of specific lncRNAs like BISPR, LINC00926, and HCP5 in disease pathways.
• Validating in silico predictions of lncRNA function through in vitro experimental data correlations.

Strengths

• Includes data from 126 total samples (92 pSS patients and 34 controls).
• Constructs a genome-wide ceRNA network with 3,035 lncRNAs and 10,838 coding genes.
• Validates regulatory roles for three key lncRNAs via in vitro experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Zhongshan Li.

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland samples.

Time Range

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Freshness

Last updated 2026-04-15 05:33:20; freshness should be verified.

Geography

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