Clinical Proteomics and Rat Validation Data for Cadmium-Induced Anxiety Intervention

A propensity-score-matched cohort of 50 cadmium-exposed individuals (25 anxious vs 25 non-anxious) provided plasma proteomics data. The dataset includes results from LC-MS/MS proteomic profiling, network pharmacology screening, molecular docking, 100ns molecular dynamics simulations, and rat behavioral and histological validation. The data was authored by Maoqin Tian and last updated on 2026-05-25.

Use Cases

• Identify anxiety-associated protein biomarkers based on 120 differentially expressed plasma proteins.
• Validate network pharmacology predictions using molecular docking and dynamics simulation results.
• Assess behavioral and neuroanatomical outcomes of a herbal intervention based on rat open-field and histology data.

Strengths

• Includes data from a matched clinical cohort of 50 individuals.
• Proteomics analysis identified 120 differentially expressed proteins.
• Validation includes 100ns molecular dynamics simulations and in vivo rat experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale at 57.7 KB.

Provenance

Source

figshare

Collection Method

Plasma proteomes profiled by LC-MS/MS, followed by computational screening and experimental rat validation.

Freshness

Last updated 2026-05-25 05:31:14; freshness should be verified.