Gut Microbial IgA Coating in Infants from Farming and Urban Cohorts

A 2026 study by Kevin Bu compares gut microbial IgA coating in infants from a traditional farming community and an urban cohort. The dataset, published on figshare under CC-BY-4.0, includes results from IgA sequencing on stool samples from 30 infants collected at an average age of 6 months. It examines associations between IgA coating of specific bacterial taxa and allergic outcomes diagnosed over the first 2 years of life.

Use Cases

• Analyze associations between IgA coating of specific bacterial taxa (e.g., P. melaninogenica, R. gnavus) and allergic outcomes based on cohort comparisons.
• Investigate the relationship between infant age and IgA coating levels of taxa like Atopobium and Corynebacterium as described in the results.
• Study the impact of breastfeeding on fecal IgA levels and maternal milk IgA response to commensals like B. infantis.
• Compare microbial composition and IgA dynamics between populations with vastly different allergy prevalences (urban vs. traditional farming).

Strengths

• Includes data from two distinct infant populations: an urban cohort (ROC, n=21) and a traditional farming community (OOM, n=9).
• Allergic outcomes were clinically diagnosed and tracked over the first 2 years of life.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (18.1 KB), indicating limited scope and likely summary-level results.

Provenance

Source

figshare

Collection Method

Immunoglobulin A sequencing (IgA-SEQ) performed on infant stool samples, with in vitro binding assays.

Time Range

Samples collected at an average infant age of 6 months, with outcomes tracked for 2 years.

Freshness

Last updated 2026-04-20 05:23:34; freshness should be verified.

Geography

Infants from an urbanized Rochester cohort and a traditional Old Order Mennonite community.