HALP Index and Mortality Across Metabolic Syndrome Spectrum: NHANES 1999-2010

NHANES data from 1999-2010 for 10,770 U.S. adults, used to examine the association between the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) index and mortality across the continuous metabolic syndrome (cMetS) spectrum. The dataset, authored by Keting Deng and last updated in 2026, contains results from survey-weighted Cox regression and competing-risk analyses. It includes hazard ratios, 10-year mortality risk percentages, and Harrell's C statistics for model discrimination.

Use Cases

• Assessing the nonlinear association between the HALP index and all-cause mortality based on hazard ratios and risk percentages.
• Evaluating joint risk classification using combined HALP and continuous metabolic syndrome (cMetS) scores.
• Comparing model discrimination improvements by adding HALP to cMetS using Harrell's C statistic changes.
• Analyzing cardiovascular mortality risk with competing-risk models as described in the results.

Strengths

• Includes data for 10,770 participants from a nationally representative survey (NHANES).
• Provides specific hazard ratios and confidence intervals (e.g., HR 0.78, 95% CI 0.69–0.88) for mortality associations.
• Reports 10-year mortality risk percentages (e.g., 15.4% in the lowest HALP tertile).
• Uses external cohort evidence for supportive validation of findings.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analysis dataset is unknown, which may limit suitability assessment.
• The primary file is a 39.5 KB DOCX, suggesting the dataset is likely a summary table rather than raw participant-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) with supportive external cohort evidence.

Collection Method

Survey-weighted Cox regression, restricted cubic splines, and competing-risk models applied to cohort data.

Time Range

NHANES data from 1999–2010, with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-05-20 05:38:42; freshness should be verified.

Geography

United States (NHANES participants).