Hepatic Zinc Deficiency and Acute Phase Response in Alcohol-Associated Hepatitis

Scott A. Read's dataset presents a nine-gene zinc signature derived from 11 publicly available transcriptomic datasets. The data likely contains results from bioinformatic analysis and in vitro validation studies on hepatocyte and immune cell cultures. The work examines the role of zinc deficiency in dampening the acute phase response in patients with alcohol-associated hepatitis.

Use Cases

• Validate the identified nine-gene zinc signature in independent patient cohorts based on the transcriptomic signature described.
• Model the relationship between hepatic zinc levels and acute phase response gene expression based on the described pathway down-regulation.
• Investigate the therapeutic potential of zinc supplementation based on the study's discussion of dietary modulation.
• Compare transcriptomic profiles of zinc-deficient versus zinc-replete immune cells based on the described in vitro models.

Strengths

• Derived from 11 publicly available transcriptomic datasets, suggesting a meta-analysis approach.
• Includes in vitro validation using primary immune cell and hepatocyte models as described in the methods.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Dataset is very small at 11.7 KB, indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, authored by Scott A. Read.

Collection Method

Bioinformatic analysis of public datasets and in vitro validation, as described.

Freshness

Last updated 2026-03-18 07:36:48; freshness should be verified.