Hippocampal Neuronal Data from an EAE Mouse Model of MS and PTSD

A dataset from a study investigating hippocampal changes in a mouse model of multiple sclerosis. The data was generated by Xinghua Zhong using morphometric analysis, whole-cell recordings, chemogenetic manipulation, and single-nucleus RNA sequencing. It was last updated on 2026-05-20.

Use Cases

• Analyzing the relationship between neuronal hypoexcitability and fear extinction deficits based on whole-cell recording data.
• Investigating transcriptional shifts in CA1 excitatory neurons based on single-nucleus RNA sequencing results.
• Studying the structural correlates of PTSD-like symptoms based on morphometric analysis of somatic atrophy.
• Evaluating the effects of chemogenetic reactivation on behavioral outcomes in a disease model.

Strengths

• Data integrates multiple experimental modalities: morphometry, electrophysiology, chemogenetics, and transcriptomics.
• The dataset is associated with a specific, peer-reviewed research hypothesis linking MS, hippocampal function, and PTSD.
• File size is 666.9 KB, indicating a focused and likely manageable dataset for analysis.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred from the research paper.
• The dataset's 666.9 KB size suggests a limited scope, potentially containing summary statistics rather than raw experimental records.

Provenance

Source

figshare, author Xinghua Zhong.

Collection Method

Generated from an experimental study using the Experimental Autoimmune Encephalomyelitis (EAE) mouse model.

Freshness

Last updated 2026-05-20 13:23:10; freshness should be verified.