Meta-Analysis Results on Homocysteine and Cognitive Impairment in Depression

A systematic review and meta-analysis by Xiaotong Liu, published in May 2026, synthesized data from 13 studies involving 1,269 patients with depression. The analysis found a significant inverse association between homocysteine levels and cognitive scores, with higher levels linked to poorer performance.

Use Cases

• Validate the association between homocysteine levels and cognitive function based on the reported correlation coefficient (r = -0.41)
• Compare standardized mean differences in cognitive performance between patient groups based on the reported SMD values
• Inform the design of prospective clinical studies on biomarkers for depression as suggested by the conclusions

Strengths

• Results are based on a meta-analysis of 13 studies involving 1,269 patients
• Methodological quality was assessed using the AHRQ checklist and GRADE approach
• Analysis includes sensitivity and subgroup analyses as mentioned in the conclusions

Limitations

• The dataset is a 12.2 KB DOCX file containing summary results, not the underlying patient-level data
• Column-level documentation for any potential supplementary tables is absent
• The geographic scope of the included studies is not specified in the provided metadata

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, Wanfang Data, and VIP databases.

Time Range

Studies from inception to December 2025 were included.

Freshness

Last updated 2026-05-13 05:57:22