Hyperglycemia-Induced Immune Tolerance in Human Alveolar Macrophages

Primary human alveolar macrophages from diabetic patients reveal a persistent immune-tolerant phenotype linked to metabolic and epigenetic changes. The dataset includes results from cytokine secretion, phagocytosis, Seahorse metabolic analysis, LC-MS metabolomics, RNA-seq, ATAC-seq, and CUT&Tag for H3K4me3. Authored by Jiang Wang and shared under CC-BY-4.0 on figshare in May 2026.

Use Cases

• Modeling immune tolerance based on cytokine secretion and phagocytosis data
• Analyzing metabolic reprogramming based on Seahorse and LC-MS metabolomics profiles
• Studying epigenetic regulation based on RNA-seq, ATAC-seq, and H3K4me3 CUT&Tag data
• Identifying candidate immunomodulatory targets for diabetic complications

Strengths

• Data is derived from primary human alveolar macrophages, a clinically relevant cell type.
• Analysis integrates multiple high-throughput techniques: metabolomics, transcriptomics, and epigenomics.
• The dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small (21.8 KB), suggesting it contains summary results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Primary human alveolar macrophages were isolated from patients with diabetes, and an in vitro hyperglycemia-induced immune memory model was established.

Freshness

Last updated 2026-05-07 04:45:50; freshness should be verified.