Hypobaric Hypoxia Effects on Lung Dendritic and T-Cell Data

A 2026 study by Xuemei Wei presents experimental data on immune cell responses in rat and mouse models of high-altitude pulmonary edema (HAPE). The dataset, shared under CC BY 4.0, contains results from single-cell sequencing, flow cytometry, and in vitro co-culture analyses. It documents the role of lung dendritic cells and CD4+ T cells in modulating HAPE progression under hypobaric hypoxia.

Use Cases

• Analyze the correlation between hypobaric hypoxia exposure levels and the recruitment count of lung dendritic cells (DCs).
• Model the relationship between TNF-α injection and the proportion of CD4+CD25+ T cells in lung tissue.
• Compare IL-6 production levels between wild-type and TNF-α-deficient mouse models of HAPE.
• Investigate the immunosuppressive phenotype differentiation of T cells as mediated by dendritic cells under hypoxic conditions.

Strengths

• Data originates from a peer-reviewed experimental study published in 2026, ensuring scientific relevance.
• Includes results from multiple validation methods: single-cell sequencing, flow cytometry, and in vitro co-culture.
• Explicitly models key immune components like dendritic cells, CD4+ T cells, TNF-α, and IL-6 in the context of HAPE.

Limitations

• The dataset is very small at 53.0 KB, indicating it contains summary or illustrative data rather than raw experimental records.
• Specific sample sizes (row counts) and measured variables (columns) for the underlying data are not provided.
• Findings are specific to rodent models (rats and mice), limiting direct translatability to human physiology.

Provenance

Source

Figshare, authored by Xuemei Wei.

Collection Method

Experimental data generated through controlled animal studies, single-cell sequencing, flow cytometry, and in vitro co-culture.

Time Range

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Freshness

Last updated on 2026-03-24.

Geography

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