Hub Genes in Immune-Active Chronic Hepatitis B from Transcriptomic Analysis

36 differentially expressed genes specific to the immune-active phase of chronic hepatitis B were identified from the GSE230397 transcriptomic dataset. The dataset, authored by Fangfang Li and last updated in May 2026, contains results from integrated bioinformatics and machine learning analyses, including four identified hub genes. It is a small, 11.5 KB Excel file shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate hub gene candidates like SLC24A4 based on the identified differentially expressed genes.
• Analyze correlations between gene expression and immune cell infiltration based on the described immune infiltration analysis.
• Train machine learning models for phase-specific biomarker identification based on the described integration of WGCNA and differential expression.
• Conduct in silico drug screening for FDA-approved compounds based on the described structure-based virtual screening targeting SLC24A4.

Strengths

• Results are validated across multiple independent datasets (GSE230397, GSE182159, GSE283471) and by western blot analysis of clinical samples.
• Analysis integrates multiple methods: differential expression, WGCNA, machine learning, and single-cell RNA sequencing validation.
• The dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (11.5 KB), indicating it likely contains summary results rather than raw expression data.
• Data may reflect bias inherent to the specific transcriptomic and scRNA-seq datasets used in the source study.

Provenance

Source

figshare, authored by Fangfang Li.

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic data (GSE230397) with validation via scRNA-seq datasets and western blot.

Time Range

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Freshness

Last updated 2026-05-04 05:31:07; freshness should be verified.

Geography

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