Common Genes Associated with Diabetic Nephropathy and Retinopathy

Juan He's research dataset identifies 206 common genes between diabetic nephropathy (DN) and diabetic retinopathy (DR), derived from transcriptome data GSE185011. The analysis, last updated in April 2026, screened 526 DN-related and 1,059 DR-related differentially expressed genes to find 6 and 4 diagnostic genes for each condition, respectively.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified diagnostic genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared molecular pathways between diabetic complications based on the 206 common genes.
• Analyzing immune cell infiltration differences, such as central memory CD4 T cells in DN and activated B cells in DR.
• Constructing regulatory networks for diagnostic genes based on the described TF-mRNA-miRNA interactions.

Strengths

• Identifies a specific set of 206 common genes between two diabetic complications.
• Reports concrete numbers: 526 DEGs for DN, 1,059 DEGs for DR, and 6 and 4 diagnostic genes for each condition.
• Includes results from multiple analytical methods: differential expression, enrichment analysis, LASSO, GSEA, and immune infiltration.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 125.0 KB, indicating limited scope.
• Geographic and demographic context for the source transcriptome data is not provided.

Provenance

Source

figshare, author Juan He.

Collection Method

Bioinformatic analysis of transcriptome dataset GSE185011 using tools like limma, ClusterProfiler, Metascape, and LASSO.

Freshness

Last updated 2026-04-28 05:24:46; freshness should be verified.